- Spezifikation
- Downloads
- Bewertungen
€448,00
ADD TO CART
Artikelnummer: E-AB-81546_50μL-ES
Recombinant Chk2 Monoclonal Antibody, 50 μL
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.
- Regulärer Preis
- €448,00 EUR
- Verkaufspreis
- €448,00 EUR
- Regulärer Preis
-
ADD TO CART
Produktspezifikation
Grundlegende Informationen
Marken: Elabscience
Versand: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Speicher: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Haltbarkeit: 12 months
Herkunftsort: China
Technical Specifications
Capacity:
Concentration:300 μg/mL
Dimension [D×W×H]:
Diameter:
Length:
Width:
High:
Volume:
Volume Range:
Speed:
Speed Range:
Max.Speed:
Max. RCF:
Temperature Range:
Operating Temperature Range:
Permissible Ambient Temperature :
Permissible Relative Humidity:
Input voltage:
Power Requirements:
Voltage/Frequency:
Sensitivity:
Specificity:
Precision:
Speed Accuracy:
Volume Accuracy:
Particle Size:
Pore Size:
Binding Capacity:
Calculated Molecular Weight:61kDa
Observed Molecular Weight:61kDa
Purity:
Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Random Error:
Acceleration/Braking time:
Aspiration Speed:
Calculated Molecular Weight:61kDa
Dilution:WB 1:500-1:1000
Driving Motor DC motor:
Em:
Ex:
Endotoxin:
Flow rate [liquid]:
Parameterinformationen
Materialien:
Erkennungsbereich:
Testprinzip:
Inter-Lebenslauf:
Intra-Lebenslauf:
Formular:
Konzentration: 300 μg/mL
Reinheit:
Komponente:
Partikelgröße:
Beispiel:
Em:
Erkennungsinstrument:
Testzeit:
Sensibilität:
Synonyme:
Erkennungsziel:
Reaktivität:
Anwendung: WB
Spezifität:
Präzision:
Quantitativ/Qualitativ:
Wiederherstellung: