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Artikelnummer: PKSH030396_50μg-ES
Recombinant Human c-MET/HGFR Protein (aa 956-1390, His & GST Tag), 50 μg
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
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Produktspezifikation
Grundlegende Informationen
Marken: Elabscience
Versand: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Speicher: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Herkunftsort: China
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Calculated Molecular Weight:76.8 kDa
Observed Molecular Weight:68 kDa
Purity: > 90 % as determined by reducing SDS-PAGE.
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Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Calculated Molecular Weight:76.8 kDa
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Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
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Anwendung: ELISA;Enzyme
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