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Artikelnummer: PDEH100520_20μg-ES
Recombinant Human CCL25 Protein(Sumo Tag), 20 μg
CCL25, also known as TECK (thymus-expressed chemokine), is a CC chemokine that regulates the trafficking of lymphocytes in the thymus and small intestine. Mature mouse CCL25 shares 40% and 81% amino acid sequence identity with an human and rat CCL25, respectively . CCL25 is produced by stromal cells in the thymus and epithelial cells of the small intestine, particularly the jejunum and ileum . It binds to and induces chemoattraction through CCR9 , and both human and mouse proteins act on human CCR9 . CCR9 is expressed on immature pre-T cells and thymocytes . CCL25 induces the homing of several lymphocyte populations to the small intestine , including Integrin alpha 4 beta 7+ gamma δ T cells , Integrin alpha E beta 7+ CD8+ T cells , and IgA-producing plasma cells . In cancer, functional CCR9 mediates the metastasis of melanoma cells to the small intestine , contributes to the CCL25-dependent migration and invasion of some breast carcinomas , and attracts mesenchymal stromal cells to CCL25-expressing multiple myelomas . CCL25 contributes to the severity of chronic inflammation in rheumatoid arthritis where it attracts CCR9+ monocytes and macrophages , in endometriosis where it promotes the invasiveness of stromal cells , and in atherosclerosis where it contributes to the accumulation of CCR9+ macrophages in arterial plaques .
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Produktspezifikation
Grundlegende Informationen
Marken: Elabscience
Versand: This product is provided as lyophilized powder which is shipped with ice packs.
Speicher: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Herkunftsort: China
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Calculated Molecular Weight:26.8 kDa
Observed Molecular Weight:34 kDa
Purity: > 90% as determined by reducing SDS-PAGE.
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Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Calculated Molecular Weight:26.8 kDa
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Endotoxin:< 10 EU/mg of the protein as determined by the LAL method.
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Synonyme: A130072A22Rik;C-C motif chemokine 25;CCL 25;CCL25;CCL25;Chemokine (C C motif) ligand 25;Chemokine (CC motif) ligand 25;Chemokine C C motif ligand 25;Chemokine CC motif ligand 25;Chemokine TECK;Ck beta 15;Ckb 15;Ckb15;MGC125074;MGC150327;SCY A25;SCYA 25;SCYA25;Small inducible cytokine A25;Small inducible cytokine A25 isoform 1 precursor;Small inducible cytokine A25 isoform 2 precursor;Small inducible cytokine subfamily A (Cys Cys) member 25;Small inducible cytokine subfamily A Cys Cys member 25;Small inducible cytokine subfamily A;member 25;Small-inducible cytokine A25;TECK;TECKvar;Thymus expressed chemokine;Thymus-expressed chemokine
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