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Artikelnummer: PKSM041233_10μg-ES
Recombinant Mouse CD226/DNAM-1 Protein (His Tag), 10 μg
Mouse DNAX accessory molecule-1(DNAM-1) is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. As an activating receptor, it interacts with the ligands CD155 and CD112, and activates natural killer (NK) cells via its immu-noreceptor tyrosine-based activatory motif (ITAM). Mature mouse DNAM-1 has extracellular domain (ECD) that contains two Ig-like C2-set domains, and possesses a cytoplasmic region that contains motifs for binding PDZ domains. DNAM-1 is expressed on several lymphoid and myeloid cell types and interacts with CD155/PVR and Nectin-2/CD112. Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells, induces dendritic cell maturation, initiates megakaryocyte and activated platelet adhesion to vascular endothelial cells, and stimulates monocyte extravasation. Conversely, it inhibits the formation of osteoclasts. Platelet-endothelium interactions that are mediated by DNAM-1 enable the metastasis of tumor cells to the lung.
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Produktspezifikation
Grundlegende Informationen
Marken: Elabscience
Versand: This product is provided as lyophilized powder which is shipped with ice packs.
Speicher: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Herkunftsort: China
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Calculated Molecular Weight:27.6 kDa
Observed Molecular Weight:35-50 kDa
Purity: > 95 % as determined by reducing SDS-PAGE.
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Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Calculated Molecular Weight:27.6 kDa
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Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
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Synonyme: BC051526;CD226;CD226 antigen;CD226 molecule;DNAM-1;DNAM1;DNAM1 adhesion glycoprotein;DNAX accessory molecule 1;DNAX accessory molecule-1;PTA1;Pta1;T lineage-specific activation antigen 1 antigen;TLiSA1;platelet and T cell activation antigen 1
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