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Artikelnummer: PKSM041480_20μg-ES
Recombinant Mouse IL-36 alpha protein(His Tag), 20 μg
Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.
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Produktspezifikation
Grundlegende Informationen
Marken: Elabscience
Versand: This product is provided as lyophilized powder which is shipped with ice packs.
Speicher: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Herkunftsort: China
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Calculated Molecular Weight:18.8 kDa
Observed Molecular Weight:17-25 kDa
Purity: > 98 % as determined by reducing SDS-PAGE.
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Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Calculated Molecular Weight:18.8 kDa
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Endotoxin: < 0.1 EU per μg of the protein as determined by the LAL method.
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Reinheit: > 98 % as determined by reducing SDS-PAGE.
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Synonyme: Interleukin-1 homolog;nterleukin-1 family member;Il1f;Il1h;IL-1F;IL-1H;FIL1 epsilon;FISP;IL-1 epsilon;IL-1F6;IL-1H1;Interleukin-1 epsilon;Interleukin-1 homolog 1;Interleukin-36 alpha;MDA-7 (Melanoma Differentiation-Associated gene 7 protein);nterleukin-1 family member 6;St16;Fil1e;Il1e;Il1f6;Il1h1;Il36a
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Anwendung: Cell culture
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