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Artikelnummer: PKSM041271_50μg-ES
Recombinant Mouse TRAIL R2/TNFRSF10B Protein (Fc Tag), 50 μg
Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.
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Produktspezifikation
Grundlegende Informationen
Marken: Elabscience
Versand: This product is provided as lyophilized powder which is shipped with ice packs.
Speicher: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Herkunftsort: China
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Calculated Molecular Weight:40.9 kDa
Observed Molecular Weight:50-75 kDa
Purity: > 95 % as determined by reducing SDS-PAGE.
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Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Calculated Molecular Weight:40.9 kDa
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Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
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Synonyme: CD262;DR5;Death Receptor 5;KILLER;TNF-Related Apoptosis-Inducing Ligand Receptor 2;TNFRSF10B;TRAIL Receptor 2;TRAIL-R2;TRAILR2;TRICK2;Tumor Necrosis Factor Receptor Superfamily Member 10B;ZTNFR9
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