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SKU: AN001670P_25μg-ES
ACE2 Monoclonal Antibody(Capture), 25 μg
ACE2 (Angiotensin-converting enzyme 2),also named as ACEH,is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE,being found predominantly in the heart,kidneys,and testes although low levels have been detected in a variety of tissues. ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2. The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility,symptoms,and outcome of 2019-nCoV/SARS-CoV-2 infection. It can be used as a potential therapeutic target of SARS-CoV-2. The calculated molecular weight of ACE2 is 92kDa but it migrates to 120kDa due to N-glycosylation . Sometimes,several cleaved fragments can also be detected as 75kDa,50 kDa or 37kDa. It has 2 isoforms produced by alternative splicing. This antibody is specific to ACE2. The location of ACE2 is membrane and cytoplasm,however it accumulates in the nucleus during the mitosis.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Concentration:1 mg/mL
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Shelf Life:12 months
Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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Dilution:ELISA Capture 2-8 μg/mL
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Application:ELISA Capture
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Research Areas:Cancer;Cell Biology;Cardiovascular
Species Reactivity:Human
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Target Synonym:ACEH;ACEII;
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Buffer:Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
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Clonality:Monoclonal
Conjugation:Unconjugated
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