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SKU: E-AB-22111_20μL-ES
Catenin beta Monoclonal Antibody, 20 μL
Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Observed Molecular Weight:92kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:WB 1:500-1:2000;IHC 1:100-1:300;IF 1:100-1:300
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Application:WB;IHC-p;IF
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Research Areas:Cancer;Cardiovascular;Neuroscience;Signal Transduction;Stem Cells
Species Reactivity:Human;Mouse;Rat
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Target Synonym:Beta catenin;Beta-catenin;Cadherin associated protein;Catenin (cadherin associated protein);beta 1;88kDa;Catenin beta 1;Catenin beta-1;CATNB;CHBCAT;CTNB1;CTNNB;CTNNB1;DKFZp686D02253;FLJ25606;FLJ37923;OTTHUMP00000162082;OTTHUMP00000165222;OTTHUMP00000165223;OTTHUMP00000209288;OTTHUMP00000209289
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Buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
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Clonality:Monoclonal
Conjugation:Unconjugated
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