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SKU: E-AB-48028_100μL-ES
DNA-RNA Hybrid Monoclonal Antibody[S9.6], 100 μL
The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNA?RNA hybrids but also binds RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and structural dependency since R?loop sequence affects binding affinity.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IF 1:200;ChIP 1:50-500;
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Application:IF;ChIP
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Species Reactivity:All
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Target Synonym:DNA-RNA hybrid;RNA/DNA hybrid
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Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
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