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SKU: E-AB-22189_60μL-ES
HIF1 bata Monoclonal Antibody, 60 μL
Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response to hypoxia (1). The HIF1 complex consists of two subunits, HIF-1α and HIF-1β, which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family (2). HIF1 regulates the transcription of a broad range of genes that facilitate responses to the hypoxic environment, including genes regulating angiogenesis, erythropoiesis, cell cycle, metabolism and apoptosis. The widely expressed HIF-1α is typically degraded rapidly in normoxic cells by the ubiquitin/proteasomal pathway. Under normoxic conditions, HIF-1α is proline hydroxylated leading to a conformational change that promotes binding to the von Hippel Lindau protein (VLH) E3 ligase complex; ubiquitination and proteasomal degradation follows (3,4). Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1α degradation and lead to its stabilization. In addition, HIF-1α can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway (5-7).HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex (8). Together with AhR, HIF-1β plays an important role in xenobiotics metabolism (8).
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Observed Molecular Weight:87kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:WB 1:1000-2000;IHC 1:100-200
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Application:WB;IHC-p;IF
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Research Areas:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism
Species Reactivity:Mouse
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Target Synonym:arnT;ARNT protein;ARNT;Aryl hydrocarbon receptor nuclear translocator;bHLHe2;Class E basic helix-loop-helix protein 2;Dioxin receptor;Dioxin receptor nuclear translocator;Drnt;HIF 1 beta;HIF 1beta;HIF-1-beta;HIF1-beta;HIF1B;HIF1beta;Hypoxia Inducible Factor 1;Hypoxia inducible factor 1 beta;Hypoxia-inducible factor 1-beta;nuclear translocator;Tango
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Buffer:PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
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Clonality:Monoclonal
Conjugation:Unconjugated
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