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SKU: E-AB-93096_60μL-ES
HMGCR Polyclonal Antibody, 60 μL
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
Warranty:
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Sterile Status:
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Technical Specifications
Capacity:
Concentration:1mg/mL
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Calculated Molecular Weight:92kDa/97kDa/99kDa
Observed Molecular Weight:100KDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:92kDa/97kDa/99kDa
Dilution:WB 1:500-1:2000
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Features and Capabilities
Application:WB
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Research Areas:Cancer;Cardiovascular;Metabolism;Signal Transduction
Species Reactivity:Human;Mouse;Rat
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Target Synonym:HMGCR;LDLCQ3;HMGCR
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Buffer:PBS with 0.02% sodium azide,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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