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SKU: E-AB-92900_120μL-ES
Human IgM Polyclonal Antibody, 120 μL
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes, joining (J) genes, and diversity (D) genes. The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:49kDa/51kDa
Observed Molecular Weight:80KDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:49kDa/51kDa
Dilution:WB 1:200-1:1000
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Application:WB
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Research Areas:Cancer;Immunology
Species Reactivity:Human
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Target Synonym:IGHM;AGM1;MU;VH
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Buffer:PBS with 0.01% thiomersal,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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