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SKU: E-AB-92991_60μL-ES
KCNJ3 Polyclonal Antibody, 60 μL
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:26kDa/56kDa
Observed Molecular Weight:56KDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:26kDa/56kDa
Dilution:WB 1:500-1:2000
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Application:WB
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Research Areas:Cardiovascular;Neuroscience
Species Reactivity:Human;Mouse;Rat
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Target Synonym:KCNJ3;GIRK1;KGA;KIR3.1
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Buffer:PBS with 0.02% sodium azide,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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