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SKU: E-AB-93282_200μL-ES
(KO Validated) CDK4 Polyclonal Antibody, 200 μL
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:20kDa/33kDa
Observed Molecular Weight:35KDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:20kDa/33kDa
Dilution:WB 1:500-1:2000;IHC 1:50-1:100;IP 1:50-1:200;IF 1:50-1:200
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Application:WB;IHC;IP;IF
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Research Areas:Cancer;Cell Biology;Epigenetics and Nuclear Signaling
Species Reactivity:Human;Mouse
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Target Synonym:CDK4; CMM3; PSK-J3; cyclin-dependent kinase 4
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Buffer:PBS with 0.01% thiomersal,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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