SKU: E-AB-93036_60μL-ES

MAP3K5 Polyclonal Antibody, 60 μL

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:China

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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

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Concentration:1mg/mL

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Calculated Molecular Weight:69kDa/154kDa

Observed Molecular Weight:155kDa

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Shelf Life:12 months

Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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Calculated Molecular Weight:69kDa/154kDa

Dilution:WB 1:500-1:2000

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Application:WB

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Research Areas:Cancer;Cell Biology;Cardiovascular

Species Reactivity:Human;Mouse

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Target Synonym:MAP3K5;ASK1;MAPKKK5;MEKK5

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Buffer:PBS with 0.02% sodium azide,50% glycerol,pH7.3.

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Clonality:Polyclonal

Conjugation:Unconjugated

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