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SKU: E-AB-93265_200μL-ES
PYCARD Polyclonal Antibody, 200 μL
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:21kDa
Observed Molecular Weight:25kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:21kDa
Dilution:WB 1:500-1:2000;IHC 1:50-1:200
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Application:WB;IHC
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Species Reactivity:Human;Mouse;Rat
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Target Synonym:A; Asc; TMS-; TNS1; masc; CARD5; TMS-1; 9130417A21Rik
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Buffer:PBS with 0.05% proclin300,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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