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SKU: PKSR030494_10μg-ES
Recombinant Human ACE2 Protein (mFc Tag), 10 μg
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Reconstitution:Not Applicable
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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Calculated Molecular Weight:110 kDa
Observed Molecular Weight:110-140 kDa
Purity: > 95 % as determined by reducing SDS-PAGE.
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Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Calculated Molecular Weight:110 kDa
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Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
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Application:ELISA
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Research Areas:Cell biology;Cardiovascular
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Bio-activity:Immobilized 2019-nCoV S1 Protein-Fc(Cat#PKSR030480) at 10μg/ml (100 μl/well) can bind Human ACE-2-mFc(Cat#PKSR030494). The ED50 of Recombinant Human ACE-2-mFc(Cat#PKSR030494) is 0.58 ug/ml.
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Formulation:Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
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