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SKU: E-AB-81602_50μL-ES
Recombinant PTBP1 Monoclonal Antibody, 50 μL
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Capacity:
Concentration:300 μg/mL
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Calculated Molecular Weight:57 kDa
Observed Molecular Weight:57 kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:57 kDa
Dilution:WB 1:1000-1:3000;IHC 1:50-1:100
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Application:WB;IHC-P
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Research Areas:Epigenetics and Nuclear Signaling
Species Reactivity:Human; Mouse; Hamster
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Target Synonym:PTBP1;HNRNP-I;HNRNPI;HNRPI;PTB;PTB-1;PTB-T;PTB2;PTB3;PTB4;pPTB
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Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
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Clonality:Rabbit Monoclonal
Conjugation:Unconjugated
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