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SKU: E-AB-81487_50μL-ES
Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody, 50 μL
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Capacity:
Concentration:300 μg/mL
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Calculated Molecular Weight:68kDa
Observed Molecular Weight:68kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:68kDa
Dilution:WB 1:500-1:1000;IHC 1:50-1:100
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Application:WB;IHC-P
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Research Areas:Epigenetics and Nuclear Signaling; Cardiovascular; Metabolism
Species Reactivity:Human
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Target Synonym:TCF7L2;HMG box transcription factor 4;HTCF-4;T-cell factor-4 variant X2;T-cell factor 4;Transcription factor 7-like 2;TCF-4
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Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
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Clonality:Rabbit Monoclonal
Conjugation:Unconjugated
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