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SKU: E-AB-22207_60μL-ES
SGK1 Monoclonal Antibody, 60 μL
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:100-200
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Application:IHC-p
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Research Areas:Cancer;Developmental Biology;Signal Transduction;Stem Cells
Species Reactivity:Human;Mouse;Rat
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Target Synonym:OTTHUMP00000017247;Serine/threonine protein kinase SGK;Serine/threonine protein kinase Sgk1;Serine/threonine-protein kinase Sgk1;Serum and glucocorticoid regulated kinase;Serum/glucocorticoid regulated kinase 1;Serum/glucocorticoid regulated kinase;Serum/glucocorticoid-regulated kinase 1;SGK 1;SGK;SGK1;Sgk1 variant i3;SGK1
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Buffer:PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
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Clonality:Monoclonal
Conjugation:Unconjugated
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