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SKU: E-AB-93256_120μL-ES
TET2 Polyclonal Antibody, 120 μL
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC into 5-hydroxymethylcytosine (5hmC and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC, and conversion of 5fC to 5-carboxylcytosine (5caC. Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:212kDa
Observed Molecular Weight:280KDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:212kDa
Dilution:WB 1:500-1:2000;IF 1:50-1:200
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Application:WB;IF
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Species Reactivity:Human;Mouse;Rat
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Target Synonym:Ayu17-44; Ayu17-449; mKIAA1546; E130014J05Rik
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Buffer:PBS with 0.05% proclin300,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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