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SKU: E-AB-67995_60μL-ES
ULk1 Polyclonal Antibody, 60 μL
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1 via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Calculated Molecular Weight:112kDa
Observed Molecular Weight:150kDa/140kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:112kDa
Dilution:WB 1:500-1:1000;IF 1:10-1:100
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Application:WB;IF
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Research Areas:Signal Transduction; Neuroscience; Cardiovascular; Metabolism
Species Reactivity:Human; Mouse; Rat
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Target Synonym:ULK1;ATG1;ATG1A;UNC51;Unc51.1;hATG1;ULk1
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Buffer:PBS with 0.05% proclin300,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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